ABCC3, also known as the ATP-binding cassette sub-family C member 3, is a protein that plays a crucial role in transporting various substances across cell membranes. It is part of the larger ATP-binding cassette (ABC) transporter family, which is involved in the movement of molecules like drugs, lipids, and toxins. ABCC3 is primarily expressed in the liver, kidneys, and intestines, where it helps in the excretion of harmful compounds. This protein is significant in pharmacology because it can influence the absorption and distribution of medications in the body. Variations in the ABCC3 gene may affect how individuals respond to certain drugs, making it an important factor in personalized medicine. Understanding ABCC3 can help researchers develop better therapeutic strategies and improve drug efficacy.