ABCC4
ABCC4, also known as ATP-binding cassette sub-family C member 4, is a protein encoded by the ABCC4 gene in humans. This protein is part of the ATP-binding cassette (ABC) transporter family, which plays a crucial role in transporting various molecules across cellular membranes. ABCC4 specifically helps in the efflux of organic anions, including drugs and metabolites, from cells.
The ABCC4 protein is primarily expressed in tissues such as the liver, kidney, and intestines. Its function is essential for drug metabolism and elimination, influencing the pharmacokinetics of various medications. Dysregulation of ABCC4 can impact drug efficacy and toxicity, making it a significant focus in pharmacology and toxicology research.