The expression "2 × 2 × 5 × 5" represents a multiplication of four numbers. To simplify, we can first multiply the two 2s together, which equals 4. Then, we multiply the two 5s together, resulting in 25. Next, we multiply the results of these two calculations: 4 × 25. This gives us a final product of 100. Thus, "2 × 2 × 5 × 5" equals 100, which is a whole number and can be used in various mathematical contexts, such as arithmetic and algebra.