Thrombophilia is a medical condition that increases the risk of abnormal blood clotting in the veins and arteries. This can lead to serious complications, such as deep vein thrombosis (DVT) or pulmonary embolism (PE). Thrombophilia can be inherited, meaning it is passed down through families, or acquired due to other health issues or lifestyle factors. People with thrombophilia may have specific genetic mutations or conditions that affect blood clotting. Common causes include Factor V Leiden mutation and prothrombin gene mutation. Diagnosis often involves blood tests, and treatment may include medications like anticoagulants to help prevent clots.