The submucosal plexus, also known as the Meissner's plexus, is a network of nerve fibers located in the submucosa layer of the gastrointestinal tract. It plays a crucial role in regulating digestive functions, including enzyme secretion and blood flow to the intestinal walls. This plexus is part of the enteric nervous system, which controls the gut independently of the central nervous system. The submucosal plexus primarily communicates with the muscularis externa layer, coordinating the contractions of the smooth muscles for effective digestion. It also interacts with sensory neurons to monitor the chemical composition of the gut contents, ensuring proper digestive processes occur.