rVSV-ZEBOV is a vaccine designed to protect against the Ebola virus. It uses a modified version of the vesicular stomatitis virus (VSV) that has been engineered to express a protein from the Ebola virus. This helps the immune system recognize and fight the actual virus if exposed. The vaccine has shown effectiveness in clinical trials and has been used in outbreak responses, particularly in West Africa. It is administered in a single dose and has been a crucial tool in controlling the spread of Ebola during outbreaks, contributing to public health efforts globally.