Primary sclerosing cholangitis (PSC) is a chronic liver disease that affects the bile ducts, which are tubes that carry bile from the liver to the small intestine. In PSC, these bile ducts become inflamed and scarred, leading to blockages that can cause liver damage over time. The exact cause of PSC is not fully understood, but it is often associated with autoimmune conditions, particularly ulcerative colitis. Symptoms of PSC can include fatigue, itching, and jaundice, which is a yellowing of the skin and eyes. Diagnosis typically involves blood tests, imaging studies, and sometimes a liver biopsy. While there is no cure for PSC, treatment focuses on managing symptoms and complications, and in severe cases, a liver transplant may be necessary.