Platelet-derived growth factors (PDGFs) are proteins that play a crucial role in cell growth, development, and healing. They are primarily produced by platelets, which are small cell fragments in the blood that help with clotting. PDGFs stimulate the proliferation and migration of various cell types, including fibroblasts and smooth muscle cells, which are essential for tissue repair and regeneration. These growth factors are involved in several biological processes, such as wound healing and the formation of new blood vessels, known as angiogenesis. PDGFs bind to specific receptors on the surface of target cells, triggering signaling pathways that promote cell division and survival. Their importance in both normal physiology and disease makes them a significant focus of medical research.