"Peripherally acting" refers to substances or mechanisms that exert their effects outside the central nervous system, primarily affecting the body's peripheral tissues. This term is often used in pharmacology to describe medications that target pain receptors or other systems without directly influencing the brain or spinal cord. For example, certain pain relievers, like nonsteroidal anti-inflammatory drugs (NSAIDs), work by blocking pain signals at the site of injury or inflammation rather than altering brain function. This approach can provide relief while minimizing central nervous system side effects, making it a preferred option for managing localized pain.