Monkeypox is a viral disease caused by the monkeypox virus, which is part of the same family as the smallpox virus. It primarily occurs in central and west Africa, where it can be transmitted to humans from animals, such as rodents and primates. Symptoms include fever, rash, and swollen lymph nodes, and the illness can last for several weeks. Transmission between humans can occur through direct contact with infected bodily fluids, skin lesions, or respiratory droplets. While monkeypox is generally less severe than smallpox, it can still lead to serious health complications, especially in individuals with weakened immune systems. Vaccines for smallpox may offer some protection against monkeypox.