Metalloproteinase-disintegrins are a group of enzymes that play a crucial role in various biological processes, including cell signaling, tissue remodeling, and inflammation. They are characterized by their ability to cleave proteins and are involved in the breakdown of extracellular matrix components, which is essential for normal development and wound healing. These enzymes are part of the ADAM (A Disintegrin and Metalloproteinase) family, which includes both metalloproteinase and disintegrin domains. The disintegrin domain allows them to interact with cell surface receptors, influencing cell adhesion and migration. Dysregulation of metalloproteinase-disintegrins is associated with several diseases, including cancer and arthritis.