Isocitrate dehydrogenase is an enzyme that plays a crucial role in the Krebs cycle, which is essential for cellular respiration. It catalyzes the conversion of isocitrate to alpha-ketoglutarate, producing NADH and CO2 in the process. This reaction is important for energy production in cells. There are different forms of isocitrate dehydrogenase, including IDH1 and IDH2, which are found in various tissues. Mutations in these enzymes can lead to certain diseases, including some types of cancer. Understanding isocitrate dehydrogenase is vital for research in metabolism and disease treatment.