Hyper-IgE syndrome is a rare immunodeficiency disorder characterized by elevated levels of immunoglobulin E (IgE) in the blood. This condition leads to recurrent infections, particularly of the skin and lungs, due to a weakened immune response. Individuals with hyper-IgE syndrome may also experience eczema and other allergic conditions. The syndrome is often associated with mutations in the STAT3 gene, which plays a crucial role in immune system regulation. Diagnosis typically involves clinical evaluation and laboratory tests to measure IgE levels. Treatment focuses on managing infections and symptoms, often requiring antibiotics and other supportive therapies.