Primary Immunodeficiencies are a group of disorders caused by genetic defects that affect the immune system's ability to function properly. These conditions can lead to increased susceptibility to infections, autoimmune diseases, and certain cancers. Symptoms often appear in childhood, but some may not be diagnosed until adulthood. Individuals with Primary Immunodeficiencies may experience frequent infections, delayed recovery from illnesses, and unusual infections that are rare in healthy individuals. Diagnosis typically involves blood tests and genetic testing, while treatment may include immunoglobulin therapy, antibiotics, or stem cell transplants to help manage the condition and improve immune function.