Diffuse scleroderma is a type of autoimmune disease characterized by widespread skin thickening and hardening. It affects the connective tissues, leading to changes in the skin, blood vessels, and internal organs. Symptoms may include swelling, pain, and stiffness in the hands and feet, as well as potential complications in organs like the heart, lungs, and kidneys. This condition is part of a broader group of diseases known as scleroderma, which means "hard skin." Unlike limited scleroderma, diffuse scleroderma progresses more rapidly and can lead to more severe health issues. Early diagnosis and treatment are crucial for managing symptoms and improving quality of life.