Congenital rubella syndrome (CRS) occurs when a pregnant woman contracts the rubella virus, especially during the first trimester. This infection can lead to serious birth defects in the baby, as the virus can affect the development of various organs and systems. Infants born with CRS may experience a range of health issues, including heart defects, hearing loss, and vision problems. Early diagnosis and intervention are crucial for managing these conditions, and vaccination against rubella is the most effective way to prevent CRS in future pregnancies.