Chronic myeloid leukemia (CML) is a type of cancer that affects the blood and bone marrow. It occurs when the body produces too many abnormal white blood cells, which can crowd out healthy cells. CML is often linked to a genetic change called the Philadelphia chromosome, which leads to the production of a protein that promotes cell growth. Symptoms of CML may include fatigue, weight loss, and an enlarged spleen. The disease typically progresses slowly and can be managed with targeted therapies, such as imatinib, which specifically inhibit the abnormal protein. Regular monitoring and treatment can help control the disease and improve quality of life.