Calamine lotion is a topical medication commonly used to relieve itching and discomfort caused by skin irritations, such as insect bites, poison ivy, and chickenpox. It contains a mixture of zinc oxide and ferric oxide, which gives it a pink color. The lotion works by soothing the skin and providing a cooling effect, helping to reduce inflammation. To use calamine lotion, apply it directly to the affected area with a cotton ball or clean fingers. It can be used several times a day, but it's important to follow the instructions on the label or consult a healthcare professional for proper use.