Berberine is a natural compound found in several plants, including goldenseal, barberry, and Chinese goldthread. It has been used in traditional medicine for centuries, particularly in Chinese and Ayurvedic practices, due to its potential health benefits. Research suggests that berberine may help regulate blood sugar levels, support heart health, and promote weight loss. It works by activating an enzyme called AMP-activated protein kinase (AMPK), which plays a crucial role in metabolism. However, more studies are needed to fully understand its effects and safety for long-term use.