The Zaire Ebola Virus is one of the five known species of the Ebola virus, which causes a severe and often fatal illness in humans and nonhuman primates. It was first identified in 1976 near the Ebola River in the Democratic Republic of the Congo, hence its name. The virus is transmitted through direct contact with bodily fluids of infected individuals or animals, leading to outbreaks primarily in Africa. Symptoms of Zaire Ebola Virus infection include fever, severe headache, muscle pain, and gastrointestinal issues, often progressing to bleeding and organ failure. The mortality rate can be high, sometimes exceeding 90%. Efforts to control outbreaks include quarantine measures, contact tracing, and the development of vaccines, such as the rVSV-ZEBOV vaccine, which has shown effectiveness in preventing the disease.