Vesicular Exanthema of Swine Virus (VESV) is a viral infection that primarily affects pigs. It is caused by a member of the Caliciviridae family and leads to the formation of vesicles or blisters on the skin and mucous membranes of affected animals. The disease is highly contagious among swine and can result in significant economic losses in the pig farming industry. VESV is similar to other vesicular diseases, such as Foot-and-Mouth Disease and Swine Vesicular Disease, making accurate diagnosis essential. While it primarily affects pigs, the virus poses no threat to human health. Control measures include biosecurity practices and vaccination in some regions.