The USS Spence (DE-535) was a U.S. Navy destroyer escort commissioned during World War II. Launched on 17 December 1943, she served primarily in the Pacific Theater, providing anti-submarine warfare and escort duties to protect larger vessels and convoys. The ship was named after Rear Admiral William Spence and was part of a class designed for quick maneuverability and effective defense against submarines. Tragically, the USS Spence was lost during a typhoon in December 1944, highlighting the dangers faced by naval vessels beyond enemy action.