The USS Spence (DD-512) was a Gearing-class destroyer of the United States Navy, commissioned in 1944. It served primarily during World War II and the Korean War, participating in various naval operations and providing support for amphibious assaults. The ship was named after Rear Admiral William Spence, who had a distinguished career in the Navy. USS Spence was decommissioned in 1970 and later sold for scrap, marking the end of its service in the fleet. Its legacy remains as part of the naval history of the United States.