The USS McCulloch (DD-216) was a Clemson-class destroyer of the United States Navy, launched on 19 March 1919. She was commissioned on 24 June 1920 and served primarily in the Pacific Fleet. The ship participated in various training exercises and operations, contributing to naval readiness during the interwar period. During World War II, the USS McCulloch was involved in escort missions and anti-submarine warfare in the Southwest Pacific. She was decommissioned on 1 July 1945 and later sold for scrap in 1947. The ship's service reflected the evolving role of destroyers in naval warfare throughout the 20th century.