US Route 421 is a major north-south highway in the United States, stretching approximately 940 miles. It begins in the state of North Carolina and travels through several states, including Tennessee, Kentucky, and Indiana, before ending in Michigan City, Indiana. The route serves as an important connector for various towns and cities along its path. The highway passes through diverse landscapes, including rural areas, mountains, and urban centers. It is often used for both local and long-distance travel, providing access to attractions such as Blue Ridge Parkway and Cumberland Falls State Resort Park. US Route 421 plays a vital role in regional transportation.