U.S. Route 421 is a major highway that runs through the state of Indiana. It stretches approximately 140 miles, connecting the northern part of the state to the southern regions. The route begins at the Michigan border and travels southward, passing through several towns and cities, including Indianapolis and Seymour. This highway serves as an important transportation corridor, facilitating travel and commerce within Indiana. It intersects with other major roads, enhancing connectivity for both local and long-distance travelers. U.S. Route 421 is also known for its scenic views, particularly in rural areas, making it a pleasant drive for those exploring the state.