U.S. Route 421 is a major highway that runs through the state of North Carolina. It stretches approximately 200 miles, connecting the coastal region to the western part of the state. The route passes through several towns and cities, including Wilmington, Greensboro, and Boone, providing access to various attractions and local amenities. The highway is known for its scenic views, particularly in the mountainous areas of Appalachia. It serves as an important transportation corridor for both residents and tourists, facilitating travel to popular destinations such as Blue Ridge Parkway and Hanging Rock State Park.