U.S. Route 422 is a major east-west highway in the United States, stretching approximately 150 miles. It runs through the states of Pennsylvania and Ohio, connecting several cities and towns along its path. The route begins in Philadelphia and ends in Cleveland, providing access to various local attractions and communities. The highway serves as an important transportation corridor, facilitating both commercial and personal travel. It intersects with several other major routes, enhancing connectivity in the region. U.S. Route 422 is known for its scenic views and is frequently used by commuters and travelers alike.