North Carolina Highway 421 is a major highway that runs through the state of North Carolina. It stretches approximately 150 miles, connecting the cities of Wilkesboro and Wilmington. The highway serves as an important route for both local and through traffic, facilitating access to various communities and attractions along the way. The road passes through diverse landscapes, including the Blue Ridge Mountains and coastal regions. It intersects with several other highways, enhancing connectivity within the state. NC 421 is also known for its scenic views and is frequently used by travelers exploring the natural beauty of North Carolina.