U.S. Route 280 is a major highway in the United States that runs primarily through the southeastern region. It stretches approximately 200 miles, connecting the cities of Birmingham, Alabama and Columbus, Georgia. The route serves as an important corridor for both local and long-distance travel. The highway passes through various landscapes, including urban areas, rural communities, and scenic countryside. Along the way, it intersects with several other major roads, facilitating access to key destinations and attractions in the region. U.S. Route 280 plays a vital role in the transportation network of the southeastern U.S.