U.S. Route 280 is a major highway in California that runs from the city of San Jose to the city of San Francisco. It serves as a vital connector between these two urban areas, facilitating travel and commerce. The route is known for its scenic views, particularly as it passes through the Santa Cruz Mountains. Originally part of the U.S. highway system established in the 1920s, Route 280 has undergone various upgrades and expansions over the years. It is a key route for commuters and travelers, providing access to several important locations, including Stanford University and San Francisco International Airport.