U.S. Route 280 is a major highway in the state of Alabama, stretching approximately 150 miles. It runs from the city of Birmingham in the north to the town of Phenix City in the south, providing a vital connection between various communities and regions. The route passes through several cities, including Talladega and Auburn, and serves as an important corridor for both local and interstate travel. It is known for its scenic views and access to recreational areas, making it a popular choice for both commuters and travelers exploring Alabama.