Transthyretin Amyloidosis (ATTR) is a rare disease caused by the buildup of misfolded proteins called transthyretin (TTR) in various tissues and organs. This accumulation can lead to damage and dysfunction, particularly affecting the heart, nerves, and kidneys. ATTR can be hereditary or occur sporadically, with symptoms often including fatigue, numbness, and heart problems. Diagnosis typically involves imaging tests, biopsies, and blood tests to detect TTR levels. Treatment options may include medications to stabilize the TTR protein, lifestyle changes, and in some cases, organ transplants. Early detection is crucial for managing the disease effectively.