Translocation oncogenes are genes that become cancer-promoting due to a rearrangement of their location within the genome. This process, known as translocation, can lead to the fusion of two different genes, resulting in a hybrid gene that may produce abnormal proteins. These proteins can disrupt normal cell functions, leading to uncontrolled cell growth and cancer. One well-known example of a translocation oncogene is the BCR-ABL fusion gene, which is associated with chronic myeloid leukemia (CML). In this case, a piece of chromosome 9 is swapped with a piece of chromosome 22, creating the fusion that drives the disease. Understanding translocation oncogenes is crucial for developing targeted therapies in cancer treatment.