Tissue necrosis refers to the death of cells in a specific area of the body due to injury, lack of blood flow, or infection. This process can occur in various tissues, including skin, muscle, and organs, leading to the breakdown of cellular structures. Common causes include ischemia, infections, and exposure to toxins. When tissue necrosis occurs, the affected area may become discolored, swollen, and painful. In severe cases, it can lead to complications such as gangrene, which may require surgical intervention. Early diagnosis and treatment are essential to prevent further damage and promote healing.