"The Girl Is in Trouble" (2015) features a diverse cast led by Columbus Short, who plays the main character, Ishmael. The film also stars Sofia Vergara as Maya, a pivotal figure in the story, and Sammi Rotibi as Derrick, adding depth to the narrative. Supporting roles include Michael Madsen, known for his extensive film career, and Jasmine Cephas Jones, who brings her talent to the ensemble. Together, this cast contributes to the film's exploration of themes like love, betrayal, and the complexities of urban life.