"The Binding of Isaac" is a popular indie video game created by Edmund McMillen. Released in 2011, it features a young boy named Isaac who escapes into a basement to avoid his mother's attempts to sacrifice him. The game is a top-down dungeon crawler with roguelike elements, where players navigate randomly generated levels filled with monsters and items. Players control Isaac as he battles various enemies and bosses, collecting power-ups that alter his abilities. The game is known for its dark themes, unique art style, and challenging gameplay. It has spawned several expansions and a sequel, further expanding its universe and mechanics.