South American Trypanosomiasis, also known as Chagas disease, is an infectious disease caused by the parasite Trypanosoma cruzi. It is primarily transmitted to humans through the bite of infected triatomine bugs, commonly referred to as "kissing bugs." The disease is prevalent in many parts of South America, but it can also affect individuals in Central America and Mexico. The disease has two phases: the acute phase, which may present mild symptoms like fever and fatigue, and the chronic phase, which can lead to serious health issues such as heart disease and digestive problems. Early diagnosis and treatment are crucial for managing the disease effectively.