Sisa is a character from the novel "Noli Me Tangere," written by the Filipino author José Rizal. She is depicted as a mother who suffers greatly due to the injustices of colonial rule in the Philippines. Sisa's tragic story highlights the struggles of women and the impact of societal issues on families during the Spanish colonial period. In the narrative, Sisa's mental state deteriorates as she searches for her lost sons, Basilio and Crisostomo. Her character symbolizes the pain and despair experienced by many Filipinos during that era, making her a poignant representation of the broader themes of loss and suffering in Rizal's work.