The Sinclair Method is a treatment approach for alcohol use disorder that involves the use of the medication naltrexone. This method is based on the principle of pharmacological extinction, where the medication helps reduce cravings and the pleasure associated with drinking. Patients take naltrexone before consuming alcohol, which gradually diminishes their desire to drink over time. This method was developed by Dr. John Sinclair, a psychologist who researched the effects of naltrexone on alcohol dependence. The Sinclair Method emphasizes the importance of drinking while on the medication, contrasting with traditional abstinence-based approaches. It aims to help individuals regain control over their drinking habits.