The Siege of Medina occurred in 625 CE during the early years of Islam. It was a conflict between the followers of the Prophet Muhammad and the Quraysh tribe of Mecca. The Quraysh aimed to retaliate against the Muslims for their earlier victories, leading to a siege of the city of Medina. The siege lasted for several weeks, but the Muslims, fortified by their knowledge of the terrain and strong community ties, successfully defended the city. Ultimately, the Quraysh were unable to capture Medina, which solidified the position of the Muslim community and marked a significant moment in early Islamic history.