"Room 101" is a concept from George Orwell's novel 1984. It represents a place where individuals are subjected to their greatest fears and phobias as a form of torture and psychological manipulation. The room is used by the totalitarian regime to break down resistance and enforce loyalty. In the story, the protagonist, Winston Smith, faces his worst fear in Room 101, which ultimately leads to his betrayal of his beliefs. The room symbolizes the extreme measures that oppressive governments may use to control and dominate individuals, highlighting the themes of fear and power in the novel.