The Prince-Bishops of Würzburg were high-ranking ecclesiastical leaders in the Prince-Bishopric of Würzburg, a territory in present-day Germany. They held both spiritual and temporal power from the Middle Ages until the secularization in the early 19th century. Their role combined religious authority with governance, overseeing the administration and defense of their lands. These bishops were influential figures in the Holy Roman Empire, often involved in politics and diplomacy. They contributed to the cultural and architectural development of Würzburg, commissioning notable structures like the Würzburg Residence, a UNESCO World Heritage site. Their legacy remains significant in the region's history.