Primary Sclerosing Cholangitis (PSC) is a chronic liver disease that affects the bile ducts, which are tubes that carry bile from the liver to the small intestine. In PSC, these ducts become inflamed and scarred, leading to blockages that can cause liver damage over time. The exact cause of PSC is not fully understood, but it is often associated with autoimmune conditions, particularly ulcerative colitis. Symptoms of PSC can include fatigue, itching, and jaundice, which is a yellowing of the skin and eyes. While there is no cure for PSC, treatments focus on managing symptoms and complications. In severe cases, a liver transplant may be necessary to restore health and improve quality of life.