Poxviridae is a family of viruses known for causing pox diseases in various animals, including humans. These viruses are large and complex, with a unique double-stranded DNA structure. Notable members of this family include Variola virus, which causes smallpox, and Vaccinia virus, used in the smallpox vaccine. Poxviridae viruses typically spread through direct contact with infected individuals or contaminated materials. They can cause skin lesions and other symptoms, depending on the specific virus. Vaccination has been effective in controlling diseases like smallpox, leading to its eradication in 1980.