The Variola Virus is the causative agent of smallpox, a highly contagious disease that was eradicated in 1980. It belongs to the Poxviridae family and is characterized by its large, brick-shaped structure. The virus spreads through respiratory droplets and direct contact with infected individuals or contaminated objects. Smallpox symptoms include fever, body aches, and a distinctive rash that develops into fluid-filled blisters. Vaccination with the smallpox vaccine was crucial in controlling outbreaks, leading to the global eradication of the disease. Today, the Variola Virus is stored in secure laboratories for research purposes.