Phosphatidylinositol (3,4,5)-trisphosphate, often abbreviated as PIP3, is a phospholipid that plays a crucial role in cellular signaling. It is produced in the cell membrane by the action of the enzyme phosphoinositide 3-kinase (PI3K). PIP3 serves as a docking site for proteins with specific domains, facilitating various cellular processes such as growth, survival, and metabolism. PIP3 is involved in the activation of several signaling pathways, including the AKT pathway, which is important for cell proliferation and survival. Dysregulation of PIP3 levels can lead to various diseases, including cancer, making it a significant focus of research in cell biology and medicine.