Periodic Fever Syndromes are a group of rare, inherited disorders characterized by recurrent episodes of fever and inflammation. These episodes can last from a few hours to several days and often occur at regular intervals. Common symptoms include fever, abdominal pain, joint pain, and skin rashes. These syndromes are caused by genetic mutations that affect the body's immune response. Examples include Familial Mediterranean Fever and Cryopyrin-Associated Periodic Syndromes. Diagnosis typically involves clinical evaluation and genetic testing, while treatment may include medications to reduce inflammation and manage symptoms.