Pemphigoid is a rare autoimmune skin disorder characterized by the formation of large, fluid-filled blisters. It occurs when the immune system mistakenly attacks the proteins that help anchor the skin layers together, leading to separation and blistering. The condition primarily affects older adults and can cause significant discomfort and skin irritation. There are different types of pemphigoid, including bullous pemphigoid and cicatricial pemphigoid. Symptoms often include itching, redness, and the appearance of blisters on the skin or mucous membranes. Treatment typically involves medications to suppress the immune response and manage symptoms.