Bullous pemphigoid is a rare autoimmune skin disorder characterized by large, fluid-filled blisters. It primarily affects older adults and occurs when the immune system mistakenly attacks the skin's basement membrane, leading to separation between the epidermis and dermis. This results in painful and itchy blisters, often found on areas such as the abdomen, thighs, and armpits. Diagnosis typically involves a skin biopsy and immunofluorescence testing to identify specific antibodies. Treatment usually includes corticosteroids and other immunosuppressive medications to reduce inflammation and blister formation. Early intervention can help manage symptoms and improve the quality of life for affected individuals.